Miguel Rivera, MD September 2020. Cancer Discovery 2017 Mar 7(3):288-301. Dr. Rivera’s labs and collaborators are particularly interested in: synovial sarcoma, Ewing sarcoma, clear cell sarcoma, desmoplastic small round cell sarcoma, and BCOR sarcomas. Find a provider affiliated with Mass General Brigham, founded by Massachusetts General Hospital (MGH) and Brigham and Women’s Hospital (BWH). Assistant Molecular Pathologist, Massachusetts General Hospital. ↵ † To whom correspondence should be addressed. MGH Gladys Maestre UTRGV James Lee Legacy Community Health Caleb Esteban Ponce University Monica Rivera Fordham University Miguel Arce Columbia University Moderators: Yakeel T. Quiroz MGH Luis Medina University of Houston: 12:00 pm - 12:15 pm: LUNCH BREAK: 12:15 pm - 12:30 pm: Cooking Tutorial of MGH's Special Latino/a Heritage Month Menu Flor Chavez Cook Assistant Nutrition and … At Mass General, the brightest minds in medicine collaborate on behalf of our patients to bridge innovation science with state-of-the-art clinical medicine. Researchers at the Massachusetts General Hospital Cancer Center have discovered a novel gene mutation associated with Wilms tumor, the most common pediatric kidney cancer. Get the latest news, explore events and connect with Mass General. Chromatin remodeling proteins are frequently dysregulated in human cancer, yet little is known about how they control tumorigenesis. Sutada Lotinun [...] Nabeel Bardeesy. Miguel MG is on Facebook. A pathologist is a physician who specializes in the causes and paths taken by different diseases in order to accurately diagnose an illness. by MGH molecular pathologist Miguel Rivera identified11 a protein implicated in Ewing’s sarcoma that provokes activity in cancer-causing genes when it gathers near pieces of the genome linked to tumour formation. Boulay G, Awad M, Riggi N, Archer T, Boonseng W, Rosetti N, Naigles B, Volorio A, Iyer S, Kim J, Mesirov JP, Tamayo P, Pomeroy SL, Aryee MJ, Rivera MN. A Massachusetts General Hospital research team has used epigenome editing tools to investigate how the genetic abnormality that drives Ewing sarcoma -- the second most common bone cancer in children and young adults -- unleashes tumor growth. The Pathology Basic Science Research Brochure brochure highlights the basic scientific research activities in MGH Pathology. Anesthesia, Critical Care & Pain Medicine, Billing, Insurance & Financial Assistance. The newly identified gene is mutated in about 30 percent of cases of Wilms tumor and is located on the sex-determining X chromosome, which means that a single altered copy would be sufficient for tumor formation. Copyright © 2007-2021. Wilms tumor chromatin profiles highlight stem cell properties and a renal developmental network.Aiden AP, Rivera MN, Rheinbay E, Ku M, Coffman EJ, Truong TT, Vargas SO, Lander ES, Haber DA, Bernstein BE. Miguel Rivera, MD, is investigating how abnormalities in gene regulation in pediatric brain and bone cancers (medulloblastoma and Ewing sarcoma respectively) drive the growth of these tumors. Massachusetts General Hospital ... Miguel N Rivera. Given that the mechanisms that drive pediatric tumors are poorly understood at present, we anticipate that our work will point to new therapies for these diseases. Mass General is the #1 Research Hospital in America and the only hospital to be recognized in all 16 specialties assessed by U.S. News & World Report. A detailed analysis of the epigenetics -- factors controlling when and in what tissues genes are expressed -- of Wilms tumor reveals striking similarities to stem cells normally found in fetal kidneys. Matteo Ligorio. Our work using this technology has shown that Wilms tumors exhibit chromatin features typical of stem cells and that patterns of chromatin remodeling can reveal the mechanisms of action of aberrant transcriptional regulators such as the EWS-FLI1 fusion protein in Ewing sarcoma and the transcription factor OTX2 in medulloblastoma. Pathology. Anesthesia, Critical Care & Pain Medicine, Billing, Insurance & Financial Assistance, MGH Research Institute the focus of SAC meeting, Prion-Like Domains Drive Tumor Growth in Ewing Sarcoma, Miguel N. Rivera, MD, MGH Research Scholar Profile, Scientific Advisory Committee meeting focuses on challenges facing research faculty, Molecular Genetic Pathology, American Board of Medical Genetics, Anatomic Pathology, American Board of Pathology, Great-West Healthcare (formally One Health Plan). Get the latest news on COVID-19, the vaccine and care at Mass General. Abstract. Search for condition information or for a specific treatment program. Juliet Jacobsen, MD Massachusetts General Hospital April 2020. Here we show that the BAF chromatin-remodeling complex, which is mutated in over 20% of human tumors, interacts with EWSR1, a member of a family of proteins with prion-like domains (PrLD) that are frequent partners in oncogenic fusions with transcription factors. Find a Doctor; Hospitals & Locations; Log In to Patient Gateway; COVID-19. MA  haber@helix.mgh.harvard.edu (D.A.H.) have utilized a micro- fluidic device to perform single-cell RNA sequencing of pancreatic CTCs, identi-fying three distinct populations that sug-gest multiple paths in the metastatic cascade. Practice Locations: Boston, MA. The Broad Institute’s faculty members are all faculty members of MIT, Harvard or one of the Harvard-affiliated hospitals. in Molecular Biology from Princeton University in 1996 and an M.D. The Encylopedia of DNA Elements (ENCODE) Project launched in 2003 with the long-term goal of developing a comprehensive map of functional elements in … Through mapping genomic deletions in Wilms tumor we identified WTX, an X-linked tumor suppressor gene commonly inactivated in this disease and recently implicated in colon cancer. Dr. Rivera received an A.B. 17 - 7 Uhr: 0621 1703-0 Miguel Rivera, MD, MGH Research Scholar 2019-2024 Jordan Smoller, MD, PhD, Tepper Family MGH Research Scholar 2014-2019 Filip Swirski, PhD, Patricia and … Rivera MN, Kim WJ, Wells J, Stone A, Burger A, Coffman EJ, Zhang J, Haber DA (2009). EWS-FLI1 utilizes divergent chromatin remodeling mechanisms to directly activate or repress enhancer elements in Ewing sarcoma. 8:30 - 17:00 Uhr Telefon: 0621 1703-2850 E-Mail: zentralambulanz@zi-mannheim.de. ), dting1@mgh.harvard.edu (D.T.T.) 37 Full PDFs related to this paper. Cell 2017 Sep 21;171(1):1-16. For more information about these cookies and the data Debattama Sen, PhD Member of the Faculty, Massachusetts General Hospital Cancer Center, Harvard Medical School. Detection of large-scale variation in the human genome. We offer diagnostic and treatment options for common and complex medical conditions. Let us help you navigate your in-person or virtual visit to Mass General. Colorectal cancers (CRCs) harboring KRAS or BRAF mutations are refractory to current targeted therapies. Here, we uncover an epigenetic program mediated by the NAD(+)-dependent histone deacetylase Sirtuin 6 (SIRT6) that is critical for suppression of pancreatic ductal adenocarcinoma (PDAC), one of the most lethal malignancies. Pediatric tumors are often driven by mutations in genes that directly control gene expression programs such as transcription factors and chromatin regulators. Information + Terminvergabe. 7 - 17 Uhr: 0621 1703-2150 Tel. Wilms tumor chromatin profiles highlight stem cell properties and a renal developmental network. Investigator: Sabina Signoretti, MD and Holger Moch, MD (BWH) collected, please refer to our Privacy Policy. We are now studying the function of WTX and related proteins using several in vitro and in vivo model systems. Massachusetts General Hospital researchers have identified a mechanism that controls the expression of genes regulating the growth of the most aggressive form of medulloblastoma, the most common pediatric brain tumor. Assistant Molecular Pathologist, Massachusetts General Hospital, Associate Professor of Pathology, Harvard Medical School. collected, please refer to our Privacy Policy. 2010 Jun 4;6(6):591-602. He graduated with honors from Harvard Medical School in 2001. For more information about these cookies and the data See more of Miguel Ruiz on Facebook. Molecular Pathology UnitMassachusetts General Hospital149 13th Street, 6th Floor In particular, his research focuses on how gene expression programs are altered in cancer. Please call Dr. Miguel Rivera's office for more information. Safe Care CommitmentGet the latest news on COVID-19, the vaccine and care at Mass General.Learn more. Science, 315: 642-5. get directions Ragon Institute of Mgh 149 13th St Charlestown, MA 02129 (617) 726-4354. He graduated with honors from Harvard Medical School in 2001. The MGH Dementia Care Collaborative will hold a two-part, Health and Resiliency series: September 10th & 24th from 1-2 pm presented by Miguel Rivera, MD. In particular, genome-wide chromatin profiling, which combines chromatin immunoprecipitation and high-throughput sequencing, is a powerful technology that can identify active and repressed states in the genome based on patterns of histone modifications. - A primary care provider (or PCP) is a doctor or in some cases, a nurse practitioner or physician assistant, who sees patients for everyday medical issues, such as colds and annual wellness visits. Rivera MN, Kim WJ, Wells J, Driscoll DR, Brannigan BW, Han M, Kim JC, Feinberg AP, Gerald WL, Vargas SO, Chin L, Iafrate AJ, Bell DW, Haber DA (2007). Explore fellowships, residencies, internships and other educational opportunities. Nicola Aceto. Luis Mgh is on Facebook. 2007 Feb 2;315(5812):642-5. Check appointments, communicate with your provider and pay bills online 24/7. Create a free account to download . Science. Explore fellowships, residencies, internships and other educational opportunities. Investigator: Spyros Artavanis-Tsakona, PhD (MGH) Molecular Analysis of Renal Cell Carcinoma Using Single Nucleotide Polymorphisms (SNP) Arrays. Aberrant phase separation allows the protein to build up in these areas. Pathology Associates55 Fruit StreetBoston, MA 02114-2696Phone: 617-726-2967. Miguel Rivera, MD, MGH Research Scholar 2019-2024; Jordan Smoller, MD, PhD, Tepper Family MGH Research Scholar 2014-2019; Filip Swirski, PhD, Patricia and Scott Eston MGH Research Scholar 2016-2022; Michael Talkowski, PhD, Desmond and Ann Heathwood MGH Research Scholar 2015-2020; To learn more about the Mass General Research Institute, please visit our website. Iafrate AJ, Feuk L, Rivera MN, Listewnik ML, Donahoe PK, Qi Y, Scherer SW, Lee C (2004). Molecular 'on switch' could point to treatments for pediatric brain tumor Mass. Center for Cancer Research Annual Report. EWS-FLI1 utilizes divergent chromatin remodeling mechanisms to directly activate or repress enhancer elements in Ewing sarcoma. In collaboration with Dr. Lee Zou, Drs. 149 13th St Charlestown , MA : (617) 726-4354 Locations & Directions A short summary of this paper. His research currently focuses on the connections between cancer and normal developmental processes and on the use of genomic technologies to identify pathways that are active in tumors and that may serve as therapeutic targets. Alterations in transcriptional regulators can orchestrate oncogenic gene expression programs in cancer. Here, we uncover an epigenetic program mediated by the NAD(+)-dependent histone deacetylase Sirtuin 6 (SIRT6) that is critical for suppression of pancreatic ductal adenocarcinoma (PDAC), one of the most lethal malignancies. Join Facebook to connect with Miguel MG and others you may know. Mgh Service Inc is a Florida Domestic Profit Corporation filed On December 7, 2015. He also serves as attending physician in the clinical molecular diagnostics laboratory at MGH. Support the … s Hospital and a fellowship in Molecular Diagnostics at the Harvard Combined Program. Miguel N. Rivera 1, Nabeel Bardeesy 1, Shyamala Maheswaran 1, Daniel A. Haber 1, † 1 Massachusetts General Hospital Cancer Center and Departments of Medicine, Pathology, and Surgery, Harvard Medical School, Boston, MA 02114, USA. The 2019 Scientific Advisory Committee (SAC) meeting reflected a shift in focus from the progress of research at the MGH to the challenges facing members of the hospital’s research faculty. “We set out to find the most important regulators of gene expression programs in medulloblastoma,” says senior author Miguel Rivera, MD, of the MGH Department of Pathology and the Center for Cancer Research. The Broad faculty consists of … Medicine Cabinet Mayhem. Dr. Rivera’s labs and collaborators are particularly interested in: synovial sarcoma, Ewing sarcoma, clear cell sarcoma, desmoplastic small round cell sarcoma, and BCOR sarcomas. Boulay G, Sandoval GJ, Riggi N, Iyer S, Buisson R, Naigles B, Awad ME, Rengarajan S, Volorio A, McBride MJ, Broye LC, Zou L, Stamenkovic I, Kadoch C, Rivera MN. or. Miguel N. Rivera, MD Massachusetts General Hospital Massachusetts General Hospital Phone: (617) 726-5695. mnrivera@partners.org. Miguel Rivera Wilms tumor is the most common childhood kidney cancer, afflicting roughly 500 children in the United States each year. Miguel Rivera, MD, receives a handprint from a patient during the Hyundai Hope on Wheels Handprint Ceremony for research on childhood cancer. At Mass General, the brightest minds in medicine collaborate on behalf of our patients to bridge innovation science with state-of-the-art clinical medicine. Download with Google Download with Facebook. We are now using a combination of biochemical and genomic tools to continue our analysis of these and other key transcriptional pathways in pediatric cancer. Miguel Rivera, MD, MGH Sandro Santagata, MD, PhD, BWH Shiladitya Sengupta, PhD, BWH Paul Shyn, MD, BWH Matthew Steinhauser, MD, BWH Shannon Stott, PhD, MGH Mario Suva, MD, PhD, MGH David Ting, MD, MGH DISCOVERY CAFÉ LUNCH Enjoy Lunch with … MGH Scientific Advisory Committee April 3 & 4, 2019 Simches Auditorium 185 Cambridge Street, 3rd Floor SAC 2019 Poster Session Abstracts. Miguel Rivera. Learn about career opportunities, search for positions and apply for a job. The Registered Agent on file for this company is Rivera Miguel J and is located at 7815 Sw 8th Street, N. Lauderdale, FL 33068. Sridhar Ramaswamy. An X chromosome gene, WTX, is commonly inactivated in Wilms tumor. Close. Using a high-resolution screen for DNA copy-number alterations in Wilms tumor, we identified somatic deletions targeting a previously uncharacterized gene on the X chromosome. He is also affiliated with the kidney cancer program at Dana-Farber / Harvard Cancer Center. Ultimately, this work could point the way to better treatments. We have remained at the forefront of medicine by fostering a culture of collaboration, pushing the boundaries of medical research, educating the brightest medical minds and maintaining an unwavering commitment to the diverse communities we serve. A generous $250,000 grant from Hyundai Hope on Wheels is helping Massachusetts General Hospital researcher Miguel Rivera, MD, investigate the complex processes that give rise to Wilms tumor, the most common childhood cancer of the kidney. Let us help you navigate your in-person or virtual visit to Mass General. Total downloads of all papers by Miguel N. Rivera. Learn about career opportunities, search for positions and apply for a job. Specialties Dr. Miguel Rivera has the following 2 specialties . Using genomics to identify critical pathways in pediatric tumors. Rivera MN, Kim WJ, Wells J, Driscoll DR, Brannigan BW, Han M, Kim JC, Feinberg AP, Gerald WL, Vargas SO, Chin L, Iafrate AJ, Bell DW, Haber DA. The 70th meeting of the MGH Scientific Advisory Committee focused on the MGH Research Institute, which was founded in 2015 as an organizational home for the more than 8,500 MGHers in 30 departments, centers and institutes who make up the largest hospital-based research program in the U.S. How the EWS-FLI1 fusion protein promotes tumor formation in Ewing Sarcoma is not fully understood and is the focus of new research from the lab of Miguel N. Rivera, MD. Miguel N. Rivera 1, Nabeel Bardeesy 1, Shyamala Maheswaran 1, Daniel A. Haber 1, † 1 Massachusetts General Hospital Cancer Center and Departments of Medicine, Pathology, and Surgery, Harvard Medical School, Boston, MA 02114, USA. Read more about the Rivera Lab. We are committed to providing expert care—safely and effectively. Miguel N. Rivera, MD, MGH Research Scholar Profile. Learn about the many ways you can get involved and support Mass General. An X chromosome gene, WTX, is commonly inactivated in Wilms tumor. Wilms tumor is a pediatric kidney cancer associated with inactivation of the WT1 tumor-suppressor gene in 5 to 10% of cases. Download Full PDF Package. Vikram Deshpande. Join Facebook to connect with Miguel Lindström and others you may know. 02129, Program Affiliations MGH Pathology Service Center for Cancer Research. Learn about the many ways you can get involved and support Mass General. In most cases, surgery combined with chemotherapy can kill these cells, but not all cases of Wilms tumor respond to current therapies. They are full citizens of their home institutions – including having full teaching and other responsibilities. If you need immediate assistance, call 877-SSRNHelp (877 777 6435) in the United States, or +1 212 448 2500 outside of the United States, 8:30AM to 6:00PM U.S. Eastern, Monday - Friday. COVID as a Catalyst for Meaningful Conversations When Living With Dementia. to analyze our web traffic. Finance. from Harvard Medical School in 2001. The company's filing status is listed as Active and its File Number is P15000097986. Safe Care CommitmentGet the latest news on COVID-19, the vaccine and care at Mass General.Learn more. This paper. OTX2 activity at distal regulatory elements shapes the chromatin landscape of Group 3 medulloblastoma. Nature Reviews Cancer, 5(9):699-712. Miguel Rivera, MD, is investigating how abnormalities in gene regulation in pediatric brain and bone cancers (medulloblastoma and Ewing sarcoma respectively) drive the growth of these tumors. Miguel Lindström is on Facebook. 2 Helicos BioSciences Corporation, One Kendall Square, Cambridge, MA 02139, USA. Pediatric tumors are often driven by mutations in genes that directly control gene expression programs such as transcription factors and chromatin regulators. Research topics include: genomic technologies to identify and characterize pathways implicated in pediatric solid tumors and sarcomas. Dr. Miguel N Rivera is a Pathology Specialist in Charlestown, Massachusetts. Our laboratory uses genomic technologies to identify abnormal gene regulation patterns in tumors and to analyze critical oncogenic pathways in several systems. Pathology Research activities occupy approx. The tumor suppressor WTX shuttles to the nucleus and modulates WT1 activity. Jon C. Aster, M.D., Ph.D., Professor of Pathology, Brigham and Women’s Hospital, "Notch signaling in cancer” (https://connects.catalyst.harvard.edu/Profiles/display/Person/48586) Bradley Bernstein, MD, PhD; Professor of Pathology, MGH,“Chromatin biology and cancer epigenetics” (http://bernstein.mgh.harvard.edu/) Ruben D. Carrasco, MD, PhD; Associate professor of Pathology, Dana-Farber Cancer Institute, “Functional characterization and targeting of oncogenic pathways in mouse mo… Cell Stem Cell. 2 Helicos BioSciences Corporation, One Kendall Square, Cambridge, MA 02139, USA. The genetic abnormality that drives the bone cancer Ewing sarcoma operates through two distinct processes -- both activating genes that stimulate tumor growth and suppressing those that should keep cancer from developing. WTX is the founding member of a new protein family (FAM123) and our work using a conditional knockout mouse model has shown that it regulates mesenchymal stem cells in several organs, including kidneys, bones and fat. by MGH molecular pathologist Miguel Rivera identified11 a protein implicated in Ewing’s sarcoma that provokes activity in cancer-causing genes when it gathers near pieces of the genome linked to tumour formation. Miguel Ruiz. They are full citizens of their home institutions – including having full teaching and other responsibilities. The Broad faculty consists of Zentralinstitut für Seelische Gesundheit (ZI) J 5 68159 Mannheim Telefon: 0621 1703-0 . During his postdoctoral fellowship, Dr. Rivera identified the tumor suppressor gene WTX which is implicated in both tumor formation and stem cell biology. Join Facebook to connect with Luis Mgh and others you may know. We have remained at the forefront of medicine by fostering a culture of collaboration, pushing the boundaries of medical research, educating the brightest medical minds and maintaining an unwavering commitment to the diverse communities we serve. Aberrant phase separation allows the protein to build up in these areas. Read more about the Rivera Lab from the Center for Cancer Research Annual Report. Massachusetts General Hospital (MGH) ... We set out to find the most important regulators of gene expression programs in medulloblastoma,” says senior author Miguel Rivera, MD, of the MGH Department of Pathology and the Center for Cancer Research. Tel. Miguel Rivera: MGH: 2008: Burroughs Wellcome Career Award for Medical Scientists: Robert Plenge: MGH: 2008: Burroughs Wellcome Career Award for Medical Scientists: Daniel Cahill: MGH: 2008 : Burroughs Wellcome Career Award for Medical Scientists: Ananth S. Karumanchi: BIDMC: 2008: Burroughs Wellcome Career Award for Medical Scientists: Catherine Wu: DFCI: 2007: Damon Runyon … Get the latest news on COVID-19, the vaccine and care at Mass General. He completed his Anatomic Pathology residency at Brigham and Wome? READ PAPER. Note: This provider may accept more insurance plans than shown; please call the practice to find out if your plan is accepted. Given that the mechanisms that drive pediatric tumors are poorly understood at present, we an… aryee.martin@mgh.harvard.edu (M.J.A. Dr. Rivera is the attending physician in the Center for Integrated Diagnostics. 20,000 sq.ft., with researchers receiving over $19 million in direct costs of annual research support. Cancer-Specific Retargeting of BAF Complexes by a Prion-like Domain. The General Hospital Corporation. Log In Notfall. Massachusetts General Hospital Cancer Center Charleston, MA Function of the protein kinase VRK1 in Ewing Sarcoma Funded by the Stuart Scott Memorial Fund. Our laboratory uses genomic technologies to identify abnormal gene regulation patterns in tumors and to analyze critical oncogenic pathways in several systems. Rivera MN, Haber DA (2005) Wilms tumor: connecting tumorigenesis and organ development in the kidney. Get the latest news, explore events and connect with Mass General. Miguel Rivera, M.D., from Massachusetts General Hospital aims to design new therapies for pediatric cancers by uncovering the biological mechanisms behind them. Wilms tumor, the most common pediatric kidney cancer, arises from kidney-specific stem cells and is a prime example of the connection between cancer and development. Cancer Cell. Riggi N, Knoechel B, Gillespie SM, Rheinbay E, Boulay G, Suvà ML, Rossetti NE, Boonseng WE, Oksuz O, Cook EB, Formey A, Patel A, Gymrek M, Thapar V, Deshpande V, Ting DT, Hornicek FJ, Nielsen GP, Stamenkovic I, Aryee MJ, Bernstein BE, Rivera MN. Nature Genetics, 36(9):949-51. 6 Center for Bioengineering in Medicine, Massachusetts General Hospital, Harvard Medical School, and Shriners Hospital for Children, Boston, MA 02114. We are committed to providing expert care—safely and effectively. General research team shows a mechanism that controls the expression of important genes in medulloblastoma 7 Massachusetts General Hospital Cancer Center,Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129; dhaber@mgh.harvard.edu. Read More About Dr. Rivera’s Research Using data from a high-throughput drug screen, we have developed a novel therapeutic strategy that combines targeting of the apoptotic machinery using the BCL-2 family inhibitor ABT-263 (navitoclax) in combination with a TORC1/2 inhibitor, AZD8055. NOTES: - "Affiliation" is the local physician organization to which the doctor belongs. Miguel Rivera, MD ... Hannah Shefsky, Board-Certified Music Therapist Massachusetts General Hospital June 2020. An X chromosome gene, WTX, is commonly inactivated in Wilms tumor.
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